GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7223966 | 1 | rs55868506 | chr17:61851686 | FTSJ3 | chr17:61896795-61905031:- | 0.3 | 5.82 | 1.06E-8 | Body mass index |
| THCA | cis | rs7223966 | 1 | rs55868506 | chr17:61851686 | MAP3K3 | chr17:61699775-61773669:+ | 0.27 | 5.5 | 6.12E-8 | Body mass index |
| THCA | cis | rs1027730 | 1 | rs55873072 | chr8:94090072 | C8orf83 | chr8:93895865-94029901:- | 0.27 | 4.13 | 4.34E-5 | Attention deficit hyperactivity disorder |
| THCA | cis | rs477692 | 1 | rs558764 | chr10:131426957 | MGMT | chr10:131265454-131565783:+ | -0.39 | -11.59 | 1.47E-27 | Response to temozolomide |
| THCA | cis | rs55879323 | 1 | rs55879323 | chr1:152168740 | FLG | chr1:152274651-152297679:- | -0.56 | -12.61 | 1.16E-31 | Inflammatory skin disease |
| THCA | cis | rs55879323 | 1 | rs55879323 | chr1:152168740 | FLG2 | chr1:152321214-152332482:- | -0.2 | -4.08 | 5.27E-5 | Inflammatory skin disease |
| THCA | cis | rs55879323 | 1 | rs55879323 | chr1:152168740 | HRNR | chr1:152184558-152196669:- | 0.48 | 9.08 | 2.83E-18 | Inflammatory skin disease |
| THCA | cis | rs1552244 | 1 | rs55882090 | chr3:10139082 | C3orf10 | chr3:10157333-10168873:+ | -0.2 | -4.29 | 2.2E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs55882090 | chr3:10139082 | VHL | chr3:10183319-10193744:+ | -0.18 | -4.19 | 3.32E-5 | Alzheimer's disease |
| THCA | cis | rs55883249 | 1 | rs55883249 | chr2:9741535 | IAH1 | chr2:9614670-9636671:+ | 0.16 | 3.44 | 0.000631 | 3-hydroxy-1-methylpropylmercapturic acid levels in smokers |
| THCA | cis | rs709400 | 1 | rs55885592 | chr14:104126024 | KLC1 | chr14:104029299-104167887:+ | -0.22 | -4.55 | 6.7E-6 | Body mass index |
| THCA | cis | rs2243480 | 1 | rs55895244 | chr7:65387678 | CCT6P1 | chr7:65216092-65228661:+ | 0.38 | 6 | 3.93E-9 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs55895244 | chr7:65387678 | CRCP | chr7:65579805-65619551:+ | -0.26 | -4 | 7.24E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs55895244 | chr7:65387678 | RABGEF1 | chr7:66093890-66276446:+ | 0.55 | 6.89 | 1.73E-11 | Diabetic kidney disease |
| THCA | cis | rs7216064 | 1 | rs55896768 | chr17:65913358 | C17orf58 | chr17:65987218-65989765:- | 0.25 | 5.02 | 7.36E-7 | Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma |